Mariano A Garcia-Blanco

Title: **Inventor Mariano A Garcia-Blanco: Pioneering Innovations in Autoimmune Disease Research**

Introduction

Mariano A Garcia-Blanco is an accomplished inventor based in Durham, NC, with a remarkable portfolio of 16 patents. His groundbreaking work focuses on methods and treatments related to autoimmune diseases and cancer, contributing significantly to advancements in medical science and genetics.

Latest Patents

Garcia-Blanco's latest patents include innovative methods for identifying individuals at a higher risk of developing autoimmune diseases. One notable patent is the method for identifying subjects based on genetic and/or phenotypic screening for epistatic variants in DDX39B and IL7R. This invention outlines a systematic approach to assess a human subject's risk of autoimmune diseases by analyzing biological samples for soluble Interleukin-7 receptor (sIL7R) and RNA Helicase DDX39B levels.

Another significant patent involves modulating therapies using soluble Interleukin-7 receptor (sIL7R) to treat autoimmune disorders and various cancers. This invention presents compositions and methods administering an effective amount of specific oligonucleotides, directly influencing the splicing of the IL7R pre-mRNA, thus impacting the expression of soluble isoforms.

Career Highlights

Garcia-Blanco's career has been marked by his profound contributions to the fields of immunology and genetics. He has been associated with prestigious institutions such as Duke University, where he advanced research in molecular genetics and disease prevention. His work at Virxsys Corporation further exemplifies his dedication to translating scientific discovery into practical medical solutions.

Collaborations

Throughout his career, Garcia-Blanco has collaborated with distinguished colleagues, including Gerard J McGarrity and Madaiah Puttaraju. These partnerships have fostered innovative research initiatives and have played a vital role in the development of his patented technologies.

Conclusion

In conclusion, Mariano A Garcia-Blanco stands out as a leading innovator in the field of autoimmune diseases and cancer treatment. His 16 patents reflect a commitment to advancing medical science and improving patient outcomes. Through his research and collaboration with renowned institutions and colleagues, he continues to make significant strides in understanding and treating complex health issues.