Madeleine H Li

Title: **Madeleine H Li: Innovator in Medicinal Chemistry**

Introduction

Madeleine H Li, based in Vernon Hills, IL, is a distinguished inventor with a remarkable portfolio of four patents primarily focused on medicinal chemistry. Her innovative work centers around the development of effective treatments through the inhibition of matrix metalloproteases, which are critical enzymes involved in various pathological conditions.

Latest Patents

One of her latest patents, titled “Aromatic sulfone hydroxamic acid metalloprotease inhibitor,” outlines a treatment process that involves administering a specific aromatic sulfone hydroxamic acid. This compound exhibits significant inhibitory activity against matrix metalloprotease (MMP) enzymes such as MMP-2, MMP-9, and MMP-13, while maintaining substantially less inhibition of MMP-1. The patent highlights the structural formula of the compound and delineates processes for manufacturing such compounds along with pharmaceutical compositions that utilize these inhibitors.

Career Highlights

Throughout her career, Madeleine has worked with prominent organizations such as Pharmacia Corporation and G.D. Searle & Company. Her experience in these companies has greatly influenced her innovative approach towards developing targeted therapies in the field of medicinal chemistry.

Collaborations

Madeleine has collaborated with notable professionals, including Thomas E Barta and Daniel Paul Becker. These partnerships have helped enhance her research and development efforts, leading to significant advancements in her field.

Conclusion

Madeleine H Li's contributions to the field of medicinal chemistry not only showcase her inventiveness but also highlight the impact of her research on therapeutic developments. With four patents to her name, she continues to make substantial strides in the fight against diseases associated with matrix metalloprotease activity.