The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2004
Filed:
Nov. 21, 2001
Thomas E. Barta, Evanston, IL (US);
Daniel P. Becker, Glenview, IL (US);
Louis J. Bedell, Mt. Prospect, IL (US);
Terri L. Boehm, Ballwin, MO (US);
Jeffery N. Carroll, Collinsville, IL (US);
Gary A. DeCrescenzo, St. Charles, MO (US);
Yvette M. Fobian, Labadie, MO (US);
John N. Freskos, Clayton, MO (US);
Daniel P. Getman, Chesterfield, MO (US);
Joseph J. McDonald, Ballwin, MO (US);
Madeleine H. Li, Vernon Hills, IL (US);
Susan L. Hockerman, Chicago, IL (US);
Carol Pearcy Howard, Fenton, MO (US);
Steve A. Kolodziej, Ballwin, MO (US);
Deborah A. Mischke, Defiance, MO (US);
Joseph G. Rico, Ballwin, MO (US);
Nathan W. Stehle, Ballwin, MO (US);
Michael B. Tollefson, O'Fallon, MO (US);
William F. Vernier, St. Louis, MO (US);
Clara I. Villamil, Glenview, IL (US);
Darren J. Kassab, Wildwood, MO (US);
Pharmacia Corporation, St. Louis, MO (US);
Abstract
This invention is directed to aromatic sulfone hydroxamates (also known as aromatic sulfone hydroxamic acids) and salts thereof that, inter alia, tend to inhibit matrix metalloproteinase (also known as matrix metalloprotease or MMP) activity and/or aggrecanase activity. This invention also is directed to a treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP activity and/or aggrecanase activity.