Location History:
- Chesterfield, MO (US) (2002)
- Wildwood, MO (US) (2004 - 2005)
- O'Fallon, MO (US) (2004 - 2006)
Company Filing History:
5 out of 220 
3 out of 1,323 
1 out of 2,538 Years Active: 2002-2006
Title: The Innovative Contributions of Darren J Kassab
Introduction
Darren J Kassab is a prominent inventor based in O'Fallon, MO, recognized for his extensive contributions to the field of protease inhibitors. With a total of nine patents under his name, Kassab's work is crucial in the development of therapeutics targeting various pathological conditions related to protease activity.
Latest Patents
Kassab's latest innovations include the development of piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids, which serve as effective protease inhibitors. This invention primarily focuses on inhibiting matrix metalloproteinase (MMP) activity and aggrecanase activity, both of which are significant in various biological processes. The structural formula of these hydroxamic acids corresponds as specified, highlighting their potential in treating conditions associated with MMP and aggrecanase activities. Furthermore, he has created a sulfamato hydroxamic acid compound that inhibits MMP activity, along with processes for its synthesis and methods to treat conditions linked to pathological matrix metalloproteinase activity.
Career Highlights
Kassab has an impressive career, having worked with notable companies such as Pharmacia Corporation and G.D. Searle & Company. His research and inventions have played a pivotal role in advancing the understanding and treatment of medical conditions linked to proteases.
Collaborations
Throughout his career, Kassab has collaborated with talented individuals including coworkers Terri L Boehm and Deborah A Mischke. These collaborations have contributed to the successful development of his patents and innovations, facilitating breakthroughs in the field of biochemistry and therapeutic agents.
Conclusion
Darren J Kassab's contributions to the field of protease inhibitors exemplify the impact of innovation and collaboration in scientific research. His nine patents reflect his dedication to advancing medical science, offering potential solutions for treating conditions arising from aberrant protease activity. As his work continues to evolve, Kassab remains a vital figure in the realm of biopharmaceutical advancement.