The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2005
Filed:
Sep. 05, 2003
John N. Freskos, Clayton, MO (US);
Yvette M. Fobian, Wildwood, MO (US);
Thomas E. Barta, Evanston, IL (US);
Daniel P. Becker, Glenview, IL (US);
Louis J. Bedell, Mt. Prospect, IL (US);
Terri L. Boehm, Ballwin, MO (US);
Jeffrey N. Carroll, Columbia, IL (US);
Gary A. Decrescenzo, St. Charles, MO (US);
Susan L. Hockerman, Chicago, IL (US);
Darren J. Kassab, Wildwood, MO (US);
Steve A. Kolodziej, Ballwin, MO (US);
Joseph Mcdonald, Wildwood, MO (US);
Deborah A. Mischke, Defiance, MO (US);
Monica B. Norton, St. Louis, MO (US);
Joseph G. Rico, Ballwin, MO (US);
John J. Talley, Boston, MA (US);
Clara I. Villamil, Glenview, IL (US);
Lijuan Jane Wang, Wildwood, MO (US);
John N. Freskos, Clayton, MO (US);
Yvette M. Fobian, Wildwood, MO (US);
Thomas E. Barta, Evanston, IL (US);
Daniel P. Becker, Glenview, IL (US);
Louis J. Bedell, Mt. Prospect, IL (US);
Terri L. Boehm, Ballwin, MO (US);
Jeffrey N. Carroll, Columbia, IL (US);
Gary A. DeCrescenzo, St. Charles, MO (US);
Susan L. Hockerman, Chicago, IL (US);
Darren J. Kassab, Wildwood, MO (US);
Steve A. Kolodziej, Ballwin, MO (US);
Joseph McDonald, Wildwood, MO (US);
Deborah A. Mischke, Defiance, MO (US);
Monica B. Norton, St. Louis, MO (US);
Joseph G. Rico, Ballwin, MO (US);
John J. Talley, Boston, MA (US);
Clara I. Villamil, Glenview, IL (US);
Lijuan Jane Wang, Wildwood, MO (US);
Pharmacia Corporation, St. Louis, MO (US);
Abstract
This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.