The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2006
Filed:
Apr. 25, 2003
Thomas E. Barta, Evanston, IL (US);
Daniel P. Becker, Glenview, IL (US);
Louis J. Bedell, Mt. Prospect, IL (US);
Terri L. Boehm, Ballwin, MO (US);
David L. Brown, Chesterfield, MO (US);
Jeffery N. Carroll, Columbia, IL (US);
Yiyuan Chen, Skokie, IL (US);
Yvette M. Fobian, Wildwood, MO (US);
John N. Freskos, Clayton, MO (US);
Alan F. Gasiecki, Vernon Hills, IL (US);
Margaret L. Grapperhaus, Troy, IL (US);
Robert M. Heintz, Ballwin, MO (US);
Susan L. Hockerman, Lincolnwood, IL (US);
Darren J. Kassab, O'Fallon, MO (US);
Ish K. Khanna, Libertyville, IL (US);
Stephen A. Kolodziej, Ballwin, MO (US);
Mark A. Massa, Ballwin, MO (US);
Joseph J. Mcdonald, Wildwood, MO (US);
Brent V. Mischke, Defiance, MO (US);
Deborah A. Mischke, Defiance, MO (US);
Patrick B. Mullins, St. Louis, MO (US);
Mark A. Nagy, Chesterfield, MO (US);
Monica B. Norton, St. Louis, MO (US);
Joseph G. Rico, Ballwin, MO (US);
Michelle A. Schmidt, Belleville, IL (US);
Nathan W. Stehle, Grafton, WI (US);
John J. Talley, Cambridge, MA (US);
William F. Vernier, St. Louis, MO (US);
Clara I. Villamil, Glenview, IL (US);
Lijuan J. Wang, Wildwood, MO (US);
Thomas A. Wynn, Chicago, IL (US);
Thomas E. Barta, Evanston, IL (US);
Daniel P. Becker, Glenview, IL (US);
Louis J. Bedell, Mt. Prospect, IL (US);
Terri L. Boehm, Ballwin, MO (US);
David L. Brown, Chesterfield, MO (US);
Jeffery N. Carroll, Columbia, IL (US);
Yiyuan Chen, Skokie, IL (US);
Yvette M. Fobian, Wildwood, MO (US);
John N. Freskos, Clayton, MO (US);
Alan F. Gasiecki, Vernon Hills, IL (US);
Margaret L. Grapperhaus, Troy, IL (US);
Robert M. Heintz, Ballwin, MO (US);
Susan L. Hockerman, Lincolnwood, IL (US);
Darren J. Kassab, O'Fallon, MO (US);
Ish K. Khanna, Libertyville, IL (US);
Stephen A. Kolodziej, Ballwin, MO (US);
Mark A. Massa, Ballwin, MO (US);
Joseph J. McDonald, Wildwood, MO (US);
Brent V. Mischke, Defiance, MO (US);
Deborah A. Mischke, Defiance, MO (US);
Patrick B. Mullins, St. Louis, MO (US);
Mark A. Nagy, Chesterfield, MO (US);
Monica B. Norton, St. Louis, MO (US);
Joseph G. Rico, Ballwin, MO (US);
Michelle A. Schmidt, Belleville, IL (US);
Nathan W. Stehle, Grafton, WI (US);
John J. Talley, Cambridge, MA (US);
William F. Vernier, St. Louis, MO (US);
Clara I. Villamil, Glenview, IL (US);
Lijuan J. Wang, Wildwood, MO (US);
Thomas A. Wynn, Chicago, IL (US);
Pharmacia Corporation, St. Louis, MO (US);
Abstract
This invention is directed generally to proteinase (also known as 'protease') inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as 'matrix metalloprotease' or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A, A, Y, E, E, E, and Rare as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.