The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2003
Filed:
May. 16, 2000
Susan L Hockerman, Chicago, IL (US);
Daniel P. Becker, Glenview, IL (US);
Louis J Bedell, Mt. Prospect, IL (US);
Gary A DeCrescenzo, St. Charles, MO (US);
John N Freskos, Clayton, MO (US);
Daniel P Getman, Chesterfield, MO (US);
Robert M Heintz, Ballwin, MO (US);
Madeleine H Li, Vernon Hills, MO (US);
Brent V Mischke, Defiance, MO (US);
Clara I Villamil, Glenview, IL (US);
Thomas E Barta, Evanston, IL (US);
G.D. Searle & Co., Skokie, IL (US);
Abstract
A family of molecules is disclosed that inhibit matrix metalloprotease (MMP) activity, and particularly inhibit the activity of one or more of MMP-2, MMP-9, or MMP-13, while generally exhibiting little activity against MMP-1. A contemplated compound also exhibits little inhibition of the production of TNF. A contemplated compound is an &agr;-amino-&bgr;-sulfonyl carbocyclo, heterocyclo, aryl, or heteroaryl hydroxamic acid. Also disclosed are processes for preparing a contemplated compound and for treating a mammal having a condition associated with pathological matrix metalloprotease activity.