Lawrence A Wade

Title: Innovations of Lawrence A. Wade

Introduction

Lawrence A. Wade is a prominent inventor based in La Canada-Flintridge, California. He holds a total of seven patents, showcasing his significant contributions to the field of micro-isolation and biochemical analysis. His work has advanced the understanding and manipulation of biological materials at a microscale.

Latest Patents

One of his latest patents is focused on methods and devices for micro-isolation, extraction, and/or analysis of microscale components. This invention includes a micro-isolation apparatus that utilizes a photomask to protect regions of interest from DNA-destroying illumination. The apparatus features photosensitive material that defines access wells after illumination and developing processes. Additionally, it comprises a chambered microfluidic device with channels that provide access to these wells. The device can also function without access wells, utilizing valves to control the flow of gases or liquids. Furthermore, Wade's inventions include methods for selectively isolating cellular material and conducting biochemical analysis on individual regions of interest.

Another significant patent involves biomarker sensors and methods for multi-color imaging and processing of single-molecule life signatures. This device consists of an array of active regions designed for sequential reactions. It features a transparent substrate with silane material and active regions that are less than one micron in size, capable of binding specific molecules. The spatial arrangement of these active regions allows for complex biochemical interactions.

Career Highlights

Wade has had a distinguished career, working with esteemed institutions such as the California Institute of Technology and the University of Southern California. His research has been pivotal in advancing technologies related to biological analysis and microfluidics.

Collaborations

Throughout his career, Wade has collaborated with notable individuals, including Charles Patrick Collier and Stephen R. Quake. These partnerships have contributed to the innovative developments in his field.

Conclusion

Lawrence A. Wade's contributions to the field of micro-isolation and biochemical analysis are noteworthy. His patents reflect a deep understanding of biological materials and innovative approaches to their manipulation. His work continues to influence advancements in scientific research and technology.