Company Filing History:
Years Active: 1995-2019
Title: Innovations of Keelnatham T Shanmugam
Introduction
Keelnatham T Shanmugam is a prominent inventor based in Gainesville, FL (US), known for his significant contributions to the field of biocatalysis and renewable energy production. With a total of 18 patents to his name, he has made remarkable strides in developing efficient methods for producing valuable chemical compounds from biological feedstocks.
Latest Patents
One of his latest patents focuses on "Engineering the pathway for succinate production." This invention relates to biocatalysts that enable the efficient production of succinic acid and other products from renewable biological feedstocks. The biocatalysts exhibit high efficiency for growth-coupled production of succinic acid due to genetic manipulation and metabolic evolution. Specifically, these biocatalysts can produce succinic acid at high titers and yields in mineral salts media during pH-controlled batch fermentation without the need for exogenous genetic material. The genetic modifications aim to conserve energy while eliminating alternative routes for NADH oxidation, thus enhancing succinic acid production.
Another notable patent involves "Variants of glycerol dehydrogenase having D-lactate dehydrogenase activity and uses thereof." This invention provides methods for designing and generating glycerol dehydrogenase (GlyDH) variants with altered functions compared to the parent polypeptide. It also includes nucleic acids encoding these GlyDH variants and methods for producing la
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