Karen L Madden

Title: The Innovative Contributions of Karen L Madden

Introduction

Karen L Madden is a prominent inventor based in Bellevue, WA (US), known for her significant contributions to the field of biomedical research. With a total of five patents to her name, she has made remarkable strides in developing methods for treating inflammatory diseases.

Latest Patents

Among her latest patents is a method of treating inflammatory disease using a soluble IL-20 receptor. This innovative receptor comprises two polypeptide subunits, IL-20RA and IL-20RB, which are preferably linked together. In one embodiment, one subunit is fused to the constant region of the light chain of an immunoglobulin, while the other subunit is fused to the constant region of the heavy chain. The connection between the light chain and heavy chain is achieved via a disulfide bond. Another notable patent is for a soluble receptor known as BR43x2, which includes soluble, secreted tumor necrosis factor receptor polypeptides. These polypeptides are designed to detect ligands, agonists, and antagonists, and can also be utilized in methods that modulate B cell activation.

Career Highlights

Karen L Madden has built her career at Zymogenetics, Inc., where she has been instrumental in advancing research and development in her field. Her work has not only contributed to scientific knowledge but has also paved the way for potential therapeutic applications.

Collaborations

Throughout her career, Karen has collaborated with esteemed colleagues, including Wenfeng Xu and Donald C Foster. These partnerships have enhanced her research efforts and expanded the impact of her innovations.

Conclusion

Karen L Madden's contributions to biomedical research and her innovative patents highlight her role as a leading inventor in her field. Her work continues to influence the development of treatments for inflammatory diseases, showcasing the importance of innovation in healthcare.