Zymogenetics, Inc.

Karen L Madden

Scott R Presnell

Donald C Foster

Cindy A Sprecher

Julia E Novak

Stephen R Jaspers

Wenfeng Xu

Brian A Fox

Mark W Rixon

Jane A Gross

Yasmin A Chandrasekher

James D Kelly

Emma E Moore

Cameron Brandt

Penny Thompson

Hal Blumberg

David P Yee

Cameron S Brandt

Maribeth A Eagan

Xu Wenfeng

Maribeth A Eagen

A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

Methods of treating inflammatory disease using a soluble IL-20 receptor

Soluble, secreted tumor necrosis factor receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise one cysteine-rich repeat that is homologous to other tumor necrosis factor receptors, such as transmembrane activator and CAML-interactor (TACI). The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that modulate B cell activation.

Soluble receptor BR43x2

Soluble interleukin-20 receptor

Soluble Interleukin-20 receptor

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Bellevue, WA, United States of America

Karen L Madden