Company Filing History:
Years Active: 1984-1995
Title: Kalman Polya: Innovator in Microbial Processes
Introduction
Kalman Polya is a notable inventor based in Debrecen, Hungary. He has made significant contributions to the field of microbial processes, particularly in the production of important compounds through innovative fermentation techniques. With a total of three patents to his name, Polya's work has implications in pharmaceuticals and biotechnology.
Latest Patents
Polya's latest patents include a microbial process for preparing mevinolin by a strain of Aspergillus. This invention refers to a new microbial process for preparing β,δ-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methyl-butyryloxy)-naphthalen-1-yl]-heptanoic acid δ-lactone and β,δ-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methylbutyryloxy)-naphtalen-1-yl]-heptanoic acid. This process involves the aerobic fermentation of a submerged culture of an imperfect fungus strain, utilizing a nutrient medium rich in carbon and nitrogen sources. The cultivation occurs at temperatures ranging from 25°C to 30°C, leading to the isolation of the desired products.
Another significant patent is related to the production of immunosuppressive antibiotics. This invention outlines a microbial process for producing cyclosporine antibiotic complex or its components, including cyclosporine A, B, and C. The process involves the aerobic fermentation of a filamentous fungus strain, specifically the novel Tolypocladium varium species. The cultivation is conducted under similar nutrient conditions and temperature ranges, allowing for the isolation and purification of the antibiotic complex.
Career Highlights
Throughout his career, Kalman Polya has worked with notable companies such as Biogal Gyogyszergyar and Biogal Gyogyszergyar Rt. His experience in these organizations has contributed to his expertise in microbial fermentation processes and antibiotic production.
Collaborations
Polya has collaborated with esteemed colleagues, including Janos Erdei and Gabor Ambrus. Their combined efforts have further advanced the research and development of innovative microbial processes.
Conclusion
Kalman Pol