The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 1995
Filed:
Jun. 17, 1993
Antonia Jekkel, Budapest, HU;
Eva Ilkoy, Budapest, HU;
Istvan M Szabo, Budapest, HU;
Gabor Ambrus, Budapest, HU;
Attila Andor, Budapest, HU;
Ilona Varga, Budapest, HU;
Imre Moravcsik, Budapest, HU;
Istvan Szabo, Kecskemet, HU;
Janos Erdei, Debrecen, HU;
Kalman Polya, Debrecen, HU;
Andras Kiss, Debrecen, HU;
Laszlo Cseke, Debrecen, HU;
Karoly Nagy, Debrecen, HU;
Mihaly Kaszas, Debrecen, HU;
Lajos Kiss, Debrecen, HU;
Istvan Magyi, Debrecen, HU;
Edit Halasz, Debrecen, HU;
Gyorgy Santha, Debrecen, HU;
BIOGAL Gyogyszergyar RT, Debrecen, HU;
Abstract
The invention refers to a new microbial process for preparing .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy l-butyryloxy)-naphthalen-1-yl]-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy lbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), ##STR1## by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25.degree. to 30.degree. C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.