The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 1992
Filed:
Dec. 20, 1989
Antonia Jekkel nee Bokany, Budapest, HU;
Gabor Ambrus, Budapest, HU;
Eva Toth-Sarudy, Budapest, HU;
Istvan Mihaly, Budapest, HU;
Agota Hulber nee Dobos, Budapest, HU;
Attila Andor, Budapest, HU;
Karoly Albrecht, Budapest, HU;
Kalman Konczol, Budapest, HU;
Valeria Szell, Budapest, HU;
Eva Tomori nee Joszt, Budapest, HU;
Imre Moravcsik, Budapest, HU;
Kalman Polya, Debrecen, HU;
Janos Erdei, Debrecen, HU;
Lajos Kiss, Debrecen, HU;
Bela Makadi, Debrecen, HU;
Karoly Nagy, Debrecen, HU;
Bela Palotas, Debrecen, HU;
Etelka Deli nee Konszky, Debrecen, HU;
Karoly Buzasi, Debrecen, HU;
Aniko Molnar nee Antal, Debrecen, HU;
Gyorgy Santha, Debrecen, HU;
Vilma Szaszhegyesi, Debrecen, HU;
Biogal Gyogyszergyar, Debrecen, HU;
Abstract
The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25.degree. to 30.degree. C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.