Biogal Gyogyszergyar

Biogal Gyogyszergyar Rt.

Kalman Polya

Janos Erdei

Imre Moravcsik

Gabor Ambrus

Istvan M Szabo

Attila Andor

Gyorgy Santha

Lajos Kiss

Karoly Nagy

Karoly Albrecht

Valeria Szell

Eva Ilkoy

Antonia Jekkel

Laszlo Cseke

Istvan Csernus

Antonia Jekkel Nee Bokany

Antal Kovacs

Eva Toth-Sarudy

Bela Makadi

Kalman Konczol

Mihaly Kaszas

Andras Liptak

Pal Nanasi

Lorant Janossy

Eva Tomori Nee Joszt

Ilona Varga

Istvan Magyi

Edit Halasz

Andras Kiss

Agota Hulber Nee Dobos

Andras Neszmelyi

Istvan Kaszab

Bela Palotas

Karoly Buzasi

Etelka Deli Nee Konszky

Aniko Molnar Nee Antal

Vilma Szaszhegyesi

Istvan Mihaly

The invention refers to a new microbial process for preparing .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy l-butyryloxy)-naphthalen-1-yl]-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy lbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), ##STR1## by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25.degree. to 30.degree. C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.

Microbial process for preparing mevinolin by a strain of aspergillus

The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25.degree. to 30.degree. C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.

Microbial process for the production of immunosuppressive antibiotics

The invention relates to novel aminoacridine-.alpha.,.beta.-(D)- and -(L)-N-glycoside derivatives, the salts thereof and to a novel process for the preparation of such compounds and salts. The novel compounds have the formula I ##STR1## wherein R is hydrogen or a group of the formula II ##STR2## wherein n=0 or 1, p=1 or 2, A.sup.-p is an anion, preferably halogenide, R.sup.1 is hydrogen or a methyl group and

Aminoacridine-.alpha., .beta.-(D)- or -(L)-N-glycoside derivatives, the

Growing community of inventors

Debrecen, Hungary

Kalman Polya