Company Filing History:
15 out of 8,684 
3 out of 1,551 
1 out of 240 
Years Active: 1992-2002
Title: Joseph A Akkara: Innovator in Enzyme-Catalyzed Modifications
Introduction
Joseph A Akkara is a prominent inventor based in Holliston, MA (US), known for his significant contributions to the field of enzyme-catalyzed modifications of macromolecules. With a total of 18 patents to his name, Akkara has made remarkable strides in the application of enzymes in organic solvents.
Latest Patents
One of his latest patents focuses on the enzyme-catalyzed modifications of macromolecules in organic solvents. This innovative work involves a protease enzyme derived from Bacillus sp., which catalyzes the acylation of organic solvent-insoluble macromolecules in isooctane solution. The acyl donors used in this process include vinyl esters of fatty acids, lactones, or lactides. The reaction is unique as it occurs only when the enzyme is solubilized through ion-pairing with the anionic surfactant dioctylsulfosuccinate, sodium salt (AOT). This enzyme-based acylation has been demonstrated in macromolecules such as silk proteins, which can be reactive either as cryogenically milled powder suspended in the organic solvent or as a thin film deposited onto ZnSe slides. This selective acylation approach represents a pioneering effort in using enzymes to modify organic-insoluble macromolecules in nonaqueous media.
Career Highlights
Throughout his career, Joseph A Akkara has worked with notable organizations, including the U.S. Government as represented by the Secretary of the Army and the University of Massachusetts. His work has significantly impacted the field of enzyme technology and its applications in various industries.
Collaborations
Akkara has collaborated with esteemed colleagues such as David L Kaplan and Ferdinando F Bruno, contributing to the advancement of research in enzyme-catalyzed processes.
Conclusion
Joseph A Akkara's innovative work in enzyme-catalyzed modifications has opened new avenues for the application of enzymes in organic solvents. His contributions continue to influence the field and inspire future research in this area.
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