Jeanmarie Guenot is a prominent inventor based in San Francisco, CA, known for her significant contributions to the field of biotherapeutics. With a remarkable portfolio of 16 patents, Guenot has been at the forefront of innovative medical solutions aimed at treating cancer and other diseases. Her inventions reflect her commitment to advancing healthcare through scientific discovery and ingenuity.

Latest Patents

Among Guenot's latest patents is the development of constrained conditionally activated binding proteins, known as Conditional Bispecific Redirected Activation constructs, or COBRAs. This groundbreaking invention involves administering these constructs in an active pro-drug format. Once exposed to tumor proteases, the constructs are cleaved and activated, enabling them to bind both tumor target antigens (TTAs) and CD3. This dual binding effectively recruits T cells expressing CD3 to the tumor site, enhancing the treatment of cancer.

Another notable patent is focused on trispecific binding proteins, which comprise a domain binding to CD3, a half-life extension domain, and a domain binding to a target antigen. This invention not only includes pharmaceutical compositions but also covers nucleic acids, recombinant expression vectors, and host cells designed for producing such proteins. Additionally, methods of utilizing these trispecific antigen-binding proteins for preventing and treating various diseases, conditions, and disorders are disclosed in this patent.

Career Highlights

Throughout her career, Guenot has made substantial contributions while working with esteemed companies in the biotherapeutic field. Notably, she has been associated with **Harpoon Therapeutics, Inc.** and **Amphivena Therapeutics, Inc.**, where she played a key role in advancing therapeutic innovations.

Collaborations

Jeanmarie Guenot has collaborated with several prominent figures in the industry, including Luke Evnin and Robert B. Dubridge. These collaborations have further enriched her innovative projects and pushed the boundaries of current medical research practices.

Conclusion

Jeanmarie Guenot's work as an inventor is marked by her dedication to developing cutting-edge solutions in biotherapeutics. With a strong patent portfolio and significant industry collaborations, her efforts continue to pave the way for innovative treatments benefiting patients worldwide. Her inventions not only showcase her technical expertise but also her passion for impacting healthcare positively through science and innovation.

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