The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 10, 2024

Filed:

Feb. 02, 2021
Applicant:

Harpoon Therapeutics, Inc., South San Francisco, CA (US);

Inventors:

Patrick Baeuerle, Gauting, DE;

Luke Evnin, San Francisco, CA (US);

Jeanmarie Guenot, San Francisco, CA (US);

Vanitha Ramakrishnan, Belmont, CA (US);

Holger Wesche, San Francisco, CA (US);

Assignee:

HARPOON THERAPEUTICS, INC., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/46 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); C07K 16/18 (2013.01); C07K 16/2809 (2013.01); C07K 16/3069 (2013.01); C07K 2317/31 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/92 (2013.01);
Abstract

Provided herein are trispecific antigen-binding proteins comprising a domain binding to CD3, a half-life extension domain, and a domain binding to a target antigen. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such trispecific antigen-binding proteins. Also disclosed are methods of using the disclosed trispecific antigen-binding proteins in the prevention, and/or treatment diseases, conditions and disorders.


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