Jan Greve

Title: The Innovative Contributions of Jan Greve

Introduction

Jan Greve is a notable inventor based in Oldenzaal, Netherlands. He has made significant contributions to the field of cell enumeration and imaging technologies. With a total of nine patents to his name, Greve's work has advanced the understanding and application of immunomagnetic techniques in medical diagnostics.

Latest Patents

One of Greve's latest patents is focused on the imaging of immunomagnetically enriched rare cells. This invention provides a method for removing excess unbound ferrofluid and imaging circulating tumor cells (CTCs). The design includes vessels with preformed grooves in the viewing surface, which optimally align cells for imaging. After separating unbound particles through centrifugation, an externally-applied force transports the magnetically responsive particle-CTC complex toward a transparent collection wall. This innovative approach allows for a uniform distribution of particles, facilitating easy imaging and quantitative analysis of CTCs in disease contexts.

Another significant patent involves methods and algorithms for cell enumeration in a low-cost cytometer. This invention addresses the challenges of flow cytometry, which is widely used for assessing leukocyte subsets and bacterial contamination. Greve's novel device allows for fluorescent labeling of all cells in a biological sample, with only target cells being magnetically labeled. The system employs wedge-shaped magnets to selectively move magnetically labeled cells to the observation surface, where they can be imaged and counted. This compact cytometer system is designed to be rugged, affordable, and user-friendly, making it suitable for use in remote locations.

Career Highlights

Throughout his career, Jan Greve has worked with several companies, including Veridex, LLC and Sequoia-Turner Corporation. His experience in these organizations has contributed to his expertise in the field of cell analysis and imaging technologies.

Collaborations

Greve has collaborated with notable colleagues such as Leon W M M Terstappen and Arjan G J Tibbe. These partnerships have further enriched his research and development efforts in innovative technologies.

Conclusion

Jan Greve's contributions to the field of cell enumeration and imaging have made a significant impact on medical diagnostics. His innovative patents and collaborations highlight his dedication to advancing technology in this important area.