The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2013
Filed:
May. 18, 2009
Tyco M. Scholtens, Enschede, NL;
Frederik Schreuder, Enschede, NL;
Jan Greve, Oldenzaal, NL;
Arjan G. J. Tibbe, Deventer, NL;
Leon W. M. M. Terstappen, Amsterdam, NL;
Tyco M. Scholtens, Enschede, NL;
Frederik Schreuder, Enschede, NL;
Jan Greve, Oldenzaal, NL;
Arjan G. J. Tibbe, Deventer, NL;
Leon W. M. M. Terstappen, Amsterdam, NL;
Veridex, LLC, Raritan, NJ (US);
Abstract
A method for removing excess unbound ferrofluid and imaging immunomagnetically enriched circulating tumor cells is provided. A vessels having a preformed grooves in the viewing surface is optimally designed for cell alignment and imaging. After separating the unbound particles by centrifugation, an externally-applied force is applied to transport magnetically responsive particle-CTC complex toward the transparent collection wall. The grooved inner surface of the viewing face of the chamber provide uniform distribution of the particles for easy imaging. The invention is also useful in conducting quantitative analysis and sample preparation in conjunction with automated cell enumeration techniques as in quantitative analysis of CTC in disease.