James Heads

Title: James Heads: Innovator in Multi-Domain Proteins

Introduction

James Heads is a notable inventor based in Berkshire, GB. He has made significant contributions to the field of protein engineering, particularly in the development of multi-domain proteins with enhanced stability. With a total of 3 patents to his name, his work has implications for therapeutic antibodies and their applications.

Latest Patents

One of his latest patents focuses on "Multi-domain proteins with increased native state colloidal stability." This invention provides a method for generating multi-domain proteins, specifically antibodies, that exhibit improved colloidal stability in their native state. The method involves calculating the total net charge for each domain of the antibody at a specific pH and making modifications to the amino acid residues to minimize charge differences. Another significant patent is related to "Antibodies of the class IgG4," which describes an IgG4 antibody with specific substitutions in the heavy chain to enhance its properties.

Career Highlights

James has worked with prominent companies in the biopharmaceutical sector, including UCB Biopharma Srl and UCB Biopharma Sprl. His experience in these organizations has allowed him to contribute to advancements in therapeutic protein development.

Collaborations

Throughout his career, James has collaborated with notable professionals in the field, including Ralph Adams and David Paul Humphreys. These collaborations have further enriched his research and innovation efforts.

Conclusion

James Heads is a distinguished inventor whose work in multi-domain proteins has the potential to advance therapeutic applications significantly. His innovative approaches and collaborations highlight his commitment to enhancing protein stability and functionality.