The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2020
Filed:
Aug. 19, 2011
Applicants:
David Paul Humphreys, Berkshire, GB;
Shirley Jane Peters, Berkshire, GB;
Ralph Adams, Berkshire, GB;
James Heads, Berkshire, GB;
Inventors:
David Paul Humphreys, Berkshire, GB;
Shirley Jane Peters, Berkshire, GB;
Ralph Adams, Berkshire, GB;
James Heads, Berkshire, GB;
Assignee:
UCB BIOPHARMA SPRL, Brussels, BE;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12P 21/08 (2006.01); C07K 16/24 (2006.01); C07K 1/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/24 (2013.01);
Abstract
The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a C1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the C1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.