Igor Dmitriev

Title: Igor Dmitriev: Innovator in Adenoviral Vector Technology

Introduction

Igor Dmitriev is a prominent inventor based in Homewood, Alabama, known for his significant contributions to the field of adenoviral vector technology. With a total of 3 patents, Dmitriev has made strides in modifying adenoviral vectors to enhance their effectiveness in targeting tumor cells.

Latest Patents

Dmitriev's latest patents include innovative approaches to adenoviral vectors. One of his notable inventions is the "Adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob." This invention provides methods to modify the tropism of recombinant adenoviral vectors by altering the adenoviral fiber cell-binding protein. The result is an adenovirus with a modified fiber gene that achieves novel tropism. Another significant patent is the "Infectivity-enhanced conditionally-replicative adenovirus and uses thereof." This modified adenovirus addresses the challenge of low coxsackie-adenovirus receptor (CAR) expression on tumor cells. The fiber protein is engineered to target tumor cells, ensuring that the replication of the modified adenovirus is limited to these cells due to mutations in the E1a or E1b genes.

Career Highlights

Igor Dmitriev is affiliated with the UAB Research Foundation, where he continues to advance research in adenoviral vectors. His work has been instrumental in developing innovative solutions for cancer treatment through targeted gene therapy.

Collaborations

Dmitriev has collaborated with notable colleagues, including David T Curiel and Victor N Krasnykh, who share his commitment to advancing the field of gene therapy and adenoviral vector technology.

Conclusion

Igor Dmitriev's contributions to adenoviral vector technology highlight his role as an innovator in the field. His patents reflect a dedication to improving cancer treatment methodologies through advanced genetic engineering.