The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2003
Filed:
Feb. 03, 2000
Applicant:
Inventors:
David T. Curiel, Birmingham, AL (US);
Igor Dmitriev, Homewood, AL (US);
Victor N. Krasnykh, Birmingham, AL (US);
Joanne T. Douglas, Huntsville, AL (US);
Assignee:
UAB Research Foundation, Birmingham, AL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 7/01 ; C12N 5/06 ; C12N 5/16 ; C12N 1/509 ; C12N 1/585 ; C12N 1/586 ;
U.S. Cl.
CPC ...
C12N 7/01 ; C12N 5/06 ; C12N 5/16 ; C12N 1/509 ; C12N 1/585 ; C12N 1/586 ;
Abstract
The present invention provides a means for the propagation of adenovirus lacking the native tropism by using genetic methods to modify the fiber protein by addition of a C-terminal tag. The modified virus is then propagated in a cell line transfected with a sequence encoding an artificial receptor for the C-terminal tag on the modified fiber protein.