The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2007
Filed:
Feb. 05, 1999
Applicants:
David T. Curiel, Birmingham, AL (US);
Victor N. Krasnykh, Birmingham, AL (US);
Igor Dmitriev, Homewood, AL (US);
Inventors:
David T. Curiel, Birmingham, AL (US);
Victor N. Krasnykh, Birmingham, AL (US);
Igor Dmitriev, Homewood, AL (US);
Assignee:
The UAB Research Foundation, Birmingham, AL (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C12N 15/63 (2006.01); C12P 19/34 (2006.01); A61K 48/00 (2006.01); A61K 35/00 (2006.01); C07H 21/04 (2006.01); C12N 9/00 (2006.01); C07K 1/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention generates an adenovirus with modified fiber gene such that novel tropism is achieved. This recombinant adenovirus has a fiber gene modified in the HI loop domain.