The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 2004
Filed:
May. 12, 2000
Applicant:
Inventors:
David T. Curiel, Birmingham, AL (US);
Victor Krasnykh, Birmingham, AL (US);
Ramon Alemany, Birmingham, AL (US);
Igor Dmitriev, Homewood, AL (US);
Assignee:
The UAB Research Foundation, Birmingham, AL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/576 ; A61K 4/800 ; C12N 1/5861 ;
U.S. Cl.
CPC ...
A61K 3/576 ; A61K 4/800 ; C12N 1/5861 ;
Abstract
A modified adenovirus capable of overcoming the problem of low level of coxsackle-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber protein of the adenovirus is modified by insertion or replacement so as to target the adenovirus to tumor cells, and the replication of the modified adenovirus is limited to tumor cells due to mutations in E1a or E1b genes.