Location History:
- Tenefly, NJ (US) (2003 - 2005)
- Tenafly, NJ (US) (2003 - 2024)
Company Filing History:
6 out of 559 
4 out of 512 
4 out of 1,360 
Years Active: 2003-2024
Title: The Innovative Contributions of Howard Scher
Introduction
Howard Scher is a prominent inventor based in Tenafly, NJ (US), known for his significant contributions to cancer treatment through innovative methodologies. With a total of 10 patents to his name, Scher has made remarkable strides in the field of medical research, particularly in the application of nanoparticles for cancer therapy.
Latest Patents
One of Scher's latest patents focuses on "Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis." This patent describes a method of inducing cell death through ferroptosis by nanoparticle ingestion. The disclosure outlines the administration of high concentrations of ultrasmall nanoparticles at multiple times during treatment, combined with a nutrient-depleted environment. This approach modulates cellular metabolic pathways to induce cell death through ferroptosis, which involves iron, reactive oxygen species, and a synchronous mode of cell death execution.
Another notable patent is titled "Inhibitor-functionalized ultrasmall nanoparticles and methods thereof." This patent describes novel conjugates that contain an inhibitor, such as a PSMA inhibitor or a gastrin-releasing peptide receptor inhibitor, covalently attached to a macromolecule like a nanoparticle, polymer, or protein. These conjugates exhibit distinct properties compared to the free, unbound inhibitor or chelator construct, showcasing Scher's innovative approach to enhancing cancer treatment.
Career Highlights
Throughout his career, Howard Scher has worked with esteemed institutions, including Memorial Sloan Kettering Cancer Center and the Sloan Kettering Institute for Cancer Research. His work has significantly impacted the field of oncology, particularly in developing targeted therapies that leverage the unique properties of nanoparticles.
Collaborations
Scher has collaborated with notable colleagues, including Michelle S. Bradbury and Ulrich B. Wiesner. These collaborations have further enriched his research and contributed to the advancement of cancer treatment methodologies.
Conclusion
Howard Scher's innovative work in the field of cancer treatment through the use of nanoparticles exemplifies the potential of modern medical research. His patents and collaborations highlight his commitment to improving therapeutic strategies for cancer patients.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.