The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2005
Filed:
Jun. 25, 2003
William G. Bornmann, New York, NY (US);
Francis Sirotnak, New York, NY (US);
Howard Scher, Tenefly, NJ (US);
Ephraim Vidal, Cincinnati, OH (US);
Christopher Borella, New York, NY (US);
David Scheinberg, New York, NY (US);
William G. Bornmann, New York, NY (US);
Francis Sirotnak, New York, NY (US);
Howard Scher, Tenefly, NJ (US);
Ephraim Vidal, Cincinnati, OH (US);
Christopher Borella, New York, NY (US);
David Scheinberg, New York, NY (US);
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Abstract
The present invention provides methods for the asymmetric synthesis of (S,S,R)-(−)-actinonin and its analogs and the compounds thereby synthesized having a structural formula:where Ris an optionally substituted or halogenated alkyl, aryl, heteroalkyl or heteroaryl amine, said Rfurther comprising a cyclic or bicyclic structure; Ris methyl, CHCH, (CH)CH, C(CH), phenyl, 3,4-dichlorophenyl, biphenyl, benzyl, 4-hydroxybenzyl, piperidine, N-Boc-4-piperidine, CH-(N-Boc-4-piperidine), 4-tetrahydropyran, CH-4-tetrahydropyran, 3-methyl indolyl, 2-naphthyl, 3-pyridyl, 4-pyridyl, 3-thienyl; Ris Ror Calkyl, Ris Calkyl; and Ris NH, OH, NHOH, NHOCH, N(CH)OH, N(CH)OCH, NHCHCH, NH(CHCH), NHCH(2,4-(OCH3)Ph, NHCH(4-NO)Ph, NHN(CH), proline, or 2-hydroxymethyl pyrrolidine. Additionally, a method for the treatment of a neoplastic disease or for the inhibition of tumor cell growth each comprising the step of administering to an individual in need of such treatment a pharmacologically effective dose of the compounds of the present invention are provided.