The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2023

Filed:

Nov. 29, 2017
Applicants:

Memorial Sloan Kettering Cancer Center, New York, NY (US);

Cornell University, Ithaca, NY (US);

The Curators of the University of Missouri, Columbia, MO (US);

Inventors:

Michelle S. Bradbury, New York, NY (US);

Thomas P. Quinn, Columbia, MO (US);

Barney Yoo, New York, NY (US);

Wolfgang Weber, Larchmont, NY (US);

Karim Touijer, New York, NY (US);

Howard Scher, Tenafly, NJ (US);

Kai Ma, Ithaca, NY (US);

Ulrich Wiesner, Ithaca, NY (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 49/00 (2006.01); A61K 51/08 (2006.01); A61K 51/12 (2006.01); C07K 7/02 (2006.01); C07K 17/00 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
A61K 49/0067 (2013.01); A61K 49/0002 (2013.01); A61K 49/0056 (2013.01); A61K 51/08 (2013.01); A61K 51/088 (2013.01); A61K 51/1244 (2013.01); C07K 7/02 (2013.01); C07K 17/00 (2013.01); G01N 33/57434 (2013.01);
Abstract

Described herein are novel conjugates containing an inhibitor (e.g., a PSMA inhibitor, e.g., a gastrin-releasing peptide receptor inhibitor) and metal chelator that are covalently attached to a macromolecule (e.g., a nanoparticle, a polymer, a protein). Such conjugates exhibit distinct properties over the free, unbound inhibitor/chelator construct.


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