The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2022
Filed:
Jun. 16, 2020
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Cornell University, Ithaca, NY (US);
Michelle S. Bradbury, New York, NY (US);
Ulrich Wiesner, Ithaca, NY (US);
Michael Overholtzer, Glen Ridge, NJ (US);
Howard Scher, Tenafly, NJ (US);
Kai Ma, Ithaca, NY (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Cornell University, Ithaca, NY (US);
Abstract
Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.