Michael Overholtzer

Title: Michael Overholtzer: Innovator in Cancer Treatment

Introduction

Michael Overholtzer is a notable inventor based in Glen Ridge, NJ (US), recognized for his contributions to cancer treatment through innovative methods involving ultrasmall nanoparticles. With a total of three patents to his name, Overholtzer is at the forefront of research aimed at improving therapeutic outcomes for cancer patients.

Latest Patents

One of Overholtzer's latest patents focuses on methods of treatment using ultrasmall nanoparticles to induce cell death in nutrient-deprived cancer cells via ferroptosis. This patent describes a method of induced cell death through nanoparticle ingestion. The disclosure details the administration of high concentrations of ultrasmall nanoparticles at multiple times during treatment, combined with a nutrient-depleted environment. This approach modulates cellular metabolic pathways to induce cell death through ferroptosis, a process that involves iron, reactive oxygen species, and a synchronous mode of cell death execution.

Career Highlights

Overholtzer has worked with prestigious institutions such as Memorial Sloan Kettering Cancer Center and Cornell University. His work in these organizations has significantly contributed to the advancement of cancer treatment methodologies.

Collaborations

Some of his notable coworkers include Michelle S. Bradbury and Ulrich B. Wiesner, who have collaborated with him on various research projects.

Conclusion

Michael Overholtzer's innovative work in the field of cancer treatment exemplifies the potential of nanoparticles in medical applications. His patents and collaborations highlight his commitment to advancing cancer therapies and improving patient outcomes.