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Years Active: 2017-2024
Title: The Innovative Contributions of Honglin Chen
Introduction
Honglin Chen is a prominent inventor based in Hong Kong, CN. He has made significant contributions to the field of biotechnology, particularly in the development of live attenuated influenza vaccines and advanced materials. With a total of 5 patents, his work has had a substantial impact on both medical and technological advancements.
Latest Patents
One of Chen's latest patents is focused on live attenuated influenza B virus compositions and methods of making and using them. The NS1 protein of the influenza virus plays a crucial role in virus replication and acts as a strong interferon antagonist. This patent describes a live attenuated virus (LAIV) that utilizes a master backbone containing the influenza B (HK8038) virus, which includes a deletion of the NS1 coding region (DelNS1). The LAIV is based on novel adaptive mutations that support DelNS1 influenza B LAIV replication in vaccine-producing cells. This innovative approach shows spontaneous cold adaptation, allowing it to grow at temperatures of 30-33° C while being restricted at 37-39° C. The LAIV can protect subjects against lethal challenges from antigenically distant influenza B viruses, making it a vital strategy for creating highly attenuated and immunogenic live attenuated influenza vaccines.
Another notable patent involves a method of producing a substrate with a wrinkle pattern of a single layer of rhenium disulfide (ReS) nanoflakes. This method utilizes ammonium rhenium and sulfur powders as sources for rhenium and sulfur, respectively. The addition of a molecular sieve controls the release of the rhenium source during the deposition of ReS. The single-layer ReS is then exposed to UV light to induce the formation of a wrinkle pattern, showcasing Chen's innovative approach to material science.
Career Highlights
Honglin Chen has worked with several notable organizations, including Versitech, Inc. and City University of Hong Kong. His experience in these institutions has allowed him to collaborate on various research projects and contribute to advancements in his field.
Collaborations
Some of Chen's notable coworkers include Kwok Yung Yuen and Pui Wang. Their collaborative efforts have further enhanced the impact of his research and innovations.
Conclusion
Honglin Chen's contributions to biotechnology and material science exemplify the spirit of innovation. His patents