The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 21, 2021

Filed:

Apr. 18, 2017
Applicant:

Versitech Limited, Hong Kong, HK;

Inventors:

Honglin Chen, Hong Kong, HK;

Min Zheng, Hong Kong, HK;

Pui Wang, Hong Kong, HK;

Johnson Yiu-Nam Lau, Houston, TX (US);

Kwok Yung Yuen, Hong Kong, HK;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); A61K 39/12 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/145 (2013.01); A61K 39/12 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/5256 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16162 (2013.01); C12N 2770/20034 (2013.01); Y02A 50/30 (2018.01);
Abstract

Compositions and methods are provided for a live, attenuated influenza vaccine suitable for nasal administration. The vaccine utilizes a cold adapted influenza virus that lacks virulence factor, and includes mutations that provide replicative ability sufficient for vaccine manufacture. Vaccines so produced provide significant cross protection for non-vaccinating strains. The vaccine is safe for children under the age of 2 and adults over 49 years of age. In addition, the cold adapted, virulence factor deleted influenza virus can be adapted to provide immunity to non-influenza pathogens.


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