Pui Wang

Title: Pui Wang: Innovator in Influenza Vaccine Development

Introduction

Pui Wang is a notable inventor based in Hong Kong, CN, recognized for his contributions to the field of influenza vaccine development. With a total of 2 patents, Wang has made significant strides in creating innovative solutions to combat influenza viruses.

Latest Patents

Wang's latest patents include groundbreaking work on live attenuated influenza B virus compositions and methods of making and using them. One of his patents focuses on the NS1 protein of the influenza virus, which plays a crucial role in virus replication and acts as a strong interferon antagonist. This live attenuated virus (LAIV) utilizes a master backbone containing the influenza B (HK8038) virus, featuring a deletion of the NS1 coding region (DelNS1). The DelNS1 LAIV demonstrates spontaneous cold adaptation, thriving at temperatures of 30-33° C while being restricted at 37-39° C. This innovative vaccine can protect subjects against lethal challenges from antigenically distant influenza B viruses.

Another patent highlights a cold-adapted and virulence factor-deleted live attenuated vaccine suitable for mucosal delivery. This vaccine is designed for nasal administration and utilizes a cold-adapted influenza virus that lacks virulence factors. It includes mutations that ensure sufficient replicative ability for vaccine manufacture. The vaccines produced from this method provide significant cross-protection against non-vaccinating strains and are safe for children under the age of 2 and adults over 49 years of age. Furthermore, the cold-adapted, virulence factor-deleted influenza virus can be adapted to provide immunity to non-influenza pathogens.

Career Highlights

Pui Wang is currently associated with Versitech, Inc., where he continues to innovate in the field of vaccine development. His work is pivotal in advancing the safety and efficacy of influenza vaccines.

Collaborations

Wang collaborates with esteemed colleagues, including Honglin Chen and Kwok Yung Yuen, contributing to a dynamic research environment that fosters innovation.

Conclusion

Pui Wang's contributions to influenza vaccine development exemplify the importance of innovation in public health. His patents reflect a commitment to creating safe and effective vaccines that can protect against various strains of influenza.