The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2017
Filed:
Nov. 13, 2015
Applicant:
The University of Hong Kong, Hong Kong, CN;
Inventors:
Assignees:
THE UNIVERSITY OF HONG KONG, Hong Kong, CN;
VERSITECH LIMITED, Hong Kong, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); C12N 7/04 (2006.01); C12N 7/00 (2006.01); A61K 39/12 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/145 (2013.01); A61K 39/12 (2013.01); C12N 7/00 (2013.01); C12N 7/04 (2013.01); A61K 2039/5254 (2013.01); C12N 2760/16121 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16162 (2013.01); C12N 2760/16171 (2013.01);
Abstract
The subject invention pertains to attenuated influenza viruses, and related vaccines and methods, comprising a genetically modified viral genome. The genetically modified viral genome comprises a disruption in the non-structural (NS1) coding segment and one or more base substitution in the matrix membrane protein coding segment. The genetic modifications result in viruses that lose NS1 functionality, yet remain replication competent.