Company Filing History:

13 out of 1,209

Dana-farber-cancer Institute Inc.

patents

2 out of 755

Northeastern University

patents

2 out of 1,373

The Brigham and Women's Hospital, Inc.

patents

4. 1 out of 443

The Broad Institute, Inc.

patents

where one patent can have more than one assignee

Years Active: 2001-2023

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13 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 11725230 - Selective degradation of wild-type DNA and enrichment of mutant alleles using nuclease (2023-08-15),

2. 11371090 - Compositions and methods for molecular barcoding of DNA molecules prior to mutation enrichment and/or mutation detection (2022-06-28),

3. 11174511 - Methods and compositions for selecting and amplifying DNA targets in a single reaction mixture (2021-11-16),

4. 11174510 - Full COLD-PCR enrichment with reference blocking sequence (2021-11-16),

5. 11130992 - Methods and compositions to enable multiplex COLD-PCR (2021-09-28),

6. 10913977 - Methods and compositions to enable enrichment of minor DNA alleles by limiting denaturation time in PCR or simply enable enrichment of minor DNA alleles by limiting the denaturation time in PCR (2021-02-09),

7. 10835604 - Biomaterials for combined radiotherapy and immunotherapy of cancer (2020-11-17),

8. 10799604 - Biopolymer-nanoparticle composite implant for tumor cell tracking (2020-10-13),

9. 9957556 - Full COLD-PCR enrichment with reference blocking sequence (2018-05-01),

10. 8623603 - Full cold-PCR enrichment with reference blocking sequence (2014-01-07),

11. 8455190 - Enrichment of a target sequence (2013-06-04),

12. 7033757 - Mutation scanning array, and methods of use thereof (2006-04-25),

13. 6174680 - Method for identifying mismatch repair glycosylase reactive sites, compounds and uses thereof (2001-01-16),

Title: Gerassimos M Makrigiorgos: Innovator in Molecular Biology

Introduction

Gerassimos M Makrigiorgos is a prominent inventor based in Brookline, MA, known for his significant contributions to molecular biology. With a total of 13 patents to his name, he has made remarkable advancements in the field of genetic research and mutation detection.

Latest Patents

Among his latest patents is a method for selective degradation of wild-type DNA and enrichment of mutant alleles using nucleases. This innovative approach provides methods for preparing a target mutant nucleic acid for subsequent enrichment relative to a wild-type nucleic acid. The methods utilize nucleases that exhibit substantially higher activity on double-stranded DNA compared to single-stranded DNA or RNA. Additionally, he has developed compositions and methods for molecular barcoding of DNA molecules prior to mutation enrichment and/or mutation detection. These methods allow for the determination of the original abundance of mutant alleles of one or more barcoded target sequences following mutation enrichment and sequencing.

Career Highlights

Gerassimos has worked with esteemed institutions such as Dana-Farber Cancer Institute and Northeastern University. His work in these organizations has furthered the understanding of genetic mutations and their implications in cancer research.

Collaborations

He has collaborated with notable colleagues, including Wilfred F Ngwa and Rajiv Kumar, contributing to various research projects that aim to enhance the field of molecular biology.

Conclusion

Gerassimos M Makrigiorgos stands out as a leading inventor in the realm of molecular biology, with a focus on innovative methods for DNA analysis and mutation detection. His contributions continue to impact the scientific community significantly.

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