The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2020
Filed:
Aug. 15, 2016
Northeastern University, Boston, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Wilfred Ngwa, Orlando, FL (US);
Rajiv Kumar, Malden, MA (US);
Gerassimos Makrigiorgos, Chestnut Hill, MA (US);
Srinivas Sridhar, Newton, MA (US);
Stephanie Dougan, Boston, MA (US);
Northeastern University, Boston, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be configured as, or be a component of, brachytherapy spacers and applicators, or radiotherapy fiducial markers. The composition may be combined with marginless radiotherapy, allowing for lower doses of radiation and enhancing the immune response against cancer, including at non-irradiated sites.