The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2020
Filed:
Jul. 27, 2015
Northeastern University, Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Rajiv Kumar, Malden, MA (US);
Srinivas Sridhar, Newton, MA (US);
Wilfred Ngwa, Framingham, MA (US);
Robert Cormack, Milton, MA (US);
Gerassimos Makrigiorgos, Chestnut Hill, MA (US);
Northeastern University, Boston, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor cells. Nanoparticles bound to the tumor cells that have migrated out of the region can be detected by various imaging modalities. The implant can be in the shape of a brachytherapy spacer or radiotherapy fiducial maker or can be a coating on a brachytherapy spacer or fiducial marker. A method of treating cancer is provided by implanting one or more brachytherapy spacers or fiducial markers including the matrix material and an anti-cancer therapeutic agent dispersed within the matrix material.