Francis X Cole

Title: The Innovative Contributions of Francis X. Cole in Immunoassay Technology

Introduction: Francis X. Cole, located in Stow, Massachusetts, is an inventor known for his significant contributions to immunoassay technology. With a total of 14 patents to his name, Cole has been a driving force in developing methods and devices that enhance the detection of analytes in various applications.

Latest Patents: Among his most recent innovations is a device and method for a multi-level, semi-quantitative immunodiffusion assay. This invention relates to an immunoassay device that incorporates a semi-quantitative, multi-level method for determining the presence and quantity of an analyte. The device features a layer with a porous medium and several binding zones, each containing a defined amount of a binding reagent for analyte immobilization. It includes an inscribed capillary channel that enables the controlled migration of fluid, allowing for a quick traversal and providing semi-quantitative results. Moreover, the binding zones produce a visual change upon analyte binding, making detection straightforward.

Cole also developed a "sol capture immunoassay kit and procedure" that detects analytes in urine. This process utilizes an immunological reaction within an aqueous phase and involves forming a filterable immunocomposite containing inherently colored gold sol particles. To minimize false positives, methods such as contaminant removal and specific binding prevention are employed, ensuring more reliable results.

Career Highlights: Francis X. Cole has worked with prominent companies, including Hygeia Sciences, Inc. and Millipore Corporation, where he honed his skills and advanced his inventions. His career in the field of immunoassay is marked by ongoing innovations and improvements in detection methods.

Collaborations: Throughout his career, Cole has collaborated with notable individuals such as Eric C. Sigillo and Gene A. Davis. These collaborations have played an essential role in the development and refinement of his inventions, contributing to the overall advancement of immunoassay technology.

Conclusion: Francis X. Cole's contributions to the field of immunoassay have made a significant impact on the ability to detect and quantify analytes with greater accuracy and efficiency. With his innovative patents and collaborative efforts, Cole continues to push the boundaries of what is possible in immunoassay technology, making him a notable figure in the realm of inventions and advancements in this field.