Erkin Seker

Title: Innovations of Erkin Seker in Nucleic Acid Detection

Introduction

Erkin Seker is a prominent inventor based in Davis, CA, known for his significant contributions to the field of biosensors and nucleic acid detection. With a total of five patents to his name, Seker has developed innovative methods that enhance the detection and identification of nucleic acid biomarkers in complex biological fluids.

Latest Patents

One of his latest patents is focused on integrated electrochemical detection and purification of nucleic acid biomarkers. This biosensor platform apparatus and method can detect, purify, and identify nucleic acid (DNA and RNA) biomarkers. The method employs a two-stage molecular approach, where the first stage screens for specific nucleic acid-based biomarkers through electrochemical detection of DNA:RNA hybridization. This stage also facilitates the removal of complex media constituents using probes within a tunable nanoporous electrode. The second stage identifies the purified specific hybrids through single-molecule conductance measurements via break junction scanning. This innovative method can provide strain-level information useful for identifying antimicrobial resistance in detected pathogens.

Another notable patent involves RNA-based, amplification-free organism identification using nano-enabled electronic detection. This technique utilizes nanotechnology to electrically detect and identify RNA sequences without the need for enzymatic amplification methods or fluorescent labels. It can be scaled into large multiplexed arrays for high-throughput and rapid screening. This method is particularly effective in differentiating closely related variants of bacterial or viral species or strains, addressing the need for a quick, efficient, and inexpensive detection and identification system.

Career Highlights

Erkin Seker has worked with esteemed institutions such as the University of California and The General Hospital Corporation. His work has significantly advanced the field of biosensors and molecular detection, making him a key figure in the innovation landscape.

Collaborations

Throughout his career, Seker has collaborated with notable individuals, including Joshua Hihath and Maria Louise Marco. These collaborations have further enriched his research and development efforts in the field of nucleic acid detection.

Conclusion

Erkin Seker's innovative work in the detection and identification of nucleic acid biomarkers has made a substantial impact on the field of biosensors. His patents reflect a commitment to advancing technology in molecular detection, paving the way for more efficient and effective diagnostic methods.