The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2016
Filed:
Jun. 28, 2011
Martin L. Yarmush, Newton, MA (US);
Eric Yang, Cambridge, MA (US);
Tali Konry, Boston, MA (US);
Erkin Seker, Davis, CA (US);
Dhruv Sarin, Shrewsbury, MA (US);
Prakash Rai, Quincy, MA (US);
Martin L. Yarmush, Newton, MA (US);
Eric Yang, Cambridge, MA (US);
Tali Konry, Boston, MA (US);
Erkin Seker, Davis, CA (US);
Dhruv Sarin, Shrewsbury, MA (US);
Prakash Rai, Quincy, MA (US);
THE GENERAL HOSPITAL CORPORATION, Boston, MA (US);
Abstract
The invention relates to blood substitute compositions, and methods of use thereof. Described herein are compositions in which hemoglobin is maintained substantially in the reduced form of hemoglobin as opposed to the oxidized methemoglobin form through inclusion of an oxido-reductase enzyme and reducing agent within a vesicle with the hemoglobin. The vesicles additionally can comprise a dismutase, a catalase, and an electron acceptor, each of which contribute to either the maintenance of hemoglobin in the active oxygen carrying state or provide a benefit not achieved with free hemoglobin.