This inventor holds 55 USPTO granted patents, plus 2 CIPO patents and 2 EPO patents, primarily in Oligonucleotide Synthesis (CPC class 536 ). Top assignees: Isis Pharmaceuticals, Inc., Hoechst Marion Roussel, Marion Merrell Dow Inc.. Active years: 1993-2010.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
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Location History:
- Carlsbad, CA (US) (1993 - 1997)
- San Diego, CA (US) (1996 - 2008)
- Half Moon Bay, CA (US) (2007 - 2010)
Company Filing History:
43 out of 1,035 
9 out of 236 
2 out of 12 Years Active: 1993-2010
Areas of Expertise:
Title: Innovations and Contributions of Douglas L. Cole in Oligonucleotide Synthesis
Introduction
Douglas L. Cole, based in San Diego, CA, is a prominent inventor with a remarkable portfolio of 55 patents. His work has significantly contributed to the field of oligonucleotide synthesis, with innovative methods that enhance the efficiency and practicality of producing sulfurized oligonucleotides.
Latest Patents
Among his latest innovations, Cole has developed methods for the synthesis of sulfurized oligonucleotides. These advanced methodologies enable the formation of phosphorothioate linkages in oligonucleotides or their derivatives without requiring complex solvent mixtures or repeated washing procedures. The techniques allow for the sulfurization of oligonucleotides containing 8 to 50 nucleotides, achieving higher yields than previously documented, thus demonstrating substantial advancements in this area.
Career Highlights
Throughout his career, Douglas L. Cole has been associated with several reputable organizations. Notable companies include Isis Pharmaceuticals, Inc. and Hoechst Marion Roussel. His experience in these firms has enabled him to refine his skills and contribute to groundbreaking research and development in oligonucleotide chemistry.
Collaborations
Cole's work has often involved collaboration with esteemed colleagues such as Vasulinga T. Ravikumar and Daniel C. Capaldi. These partnerships have played a significant role in fostering innovation and advancing the scientific understanding and applications of oligonucleotides.
Conclusion
Douglas L. Cole's contributions to the field of oligonucleotide synthesis are both invaluable and impactful. With numerous patents to his name and ongoing advancements in sulfurized oligonucleotide methodologies, his work continues to influence researchers and industry professionals alike, paving the way for future innovations in this essential scientific domain.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile