The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2010
Filed:
Apr. 21, 2008
Douglas L. Cole, Half Moon Bay, CA (US);
Vasulinga Ravikumar, Carlsbad, CA (US);
Zacharia S. Cheruvallath, San Diego, CA (US);
Douglas L. Cole, Half Moon Bay, CA (US);
Vasulinga Ravikumar, Carlsbad, CA (US);
Zacharia S. Cheruvallath, San Diego, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.