The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 22, 2005

Filed:

Aug. 30, 2002
Applicants:

Vasulinga T. Ravikumar, Carlsbad, CA (US);

Muthiah Manoharan, Carlsbad, CA (US);

Daniel C. Capaldi, San Diego, CA (US);

Achim Krotz, San Diego, CA (US);

Douglas L. Cole, San Diego, CA (US);

Andrei Guzaev, Carlsbad, CA (US);

Inventors:

Vasulinga T. Ravikumar, Carlsbad, CA (US);

Muthiah Manoharan, Carlsbad, CA (US);

Daniel C. Capaldi, San Diego, CA (US);

Achim Krotz, San Diego, CA (US);

Douglas L. Cole, San Diego, CA (US);

Andrei Guzaev, Carlsbad, CA (US);

Assignee:

ISIS Pharmaceuticals, Inc., Carlsbad, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H021/00 ;
U.S. Cl.
CPC ...
Abstract

Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.


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