Company Filing History:
Years Active: 2022-2025
Title: Innovations by Daniel Groff
Introduction
Daniel Groff is an accomplished inventor based in Alameda, CA (US). He has made significant contributions to the field of biotechnology, particularly in the production of proteins with disulfide bonds. With a total of 3 patents to his name, Groff's work has the potential to impact various applications in medicine and research.
Latest Patents
One of Groff's latest patents involves strains having an oxidative cytoplasm. This disclosure provides a strain that lacks thioredoxin reductase activity encoded by trxB and thioredoxin 1 activity encoded by trxA, as well as glutathione reductase activity encoded by gor. The strain expresses a mutated AhpC protein that has glutathione reductase activity and a cytosolic prokaryotic disulfide isomerase. This innovative strain can be used to efficiently produce proteins that have disulfide bonds.
Another notable patent by Groff details methods of producing full-length antibodies. This disclosure provides a method that yields at least about 200 mg/L of full-length antibodies. The cells used in this method typically have an oxidative cytoplasm, which is crucial for maintaining the three-dimensional structure and stability of proteins that contain disulfide bonds. In some instances, the molar ratio of the produced heavy chain (HC) and light chain (LC) amounts from culturing ranges from about 1:1 to about 1:3.
Career Highlights
Daniel Groff is currently employed at Sutro Biopharma, Inc., where he continues to innovate and develop new biotechnological solutions. His work at Sutro Biopharma focuses on advancing the production of therapeutic proteins, which are essential for various medical treatments.
Collaborations
Groff collaborates with several professionals in his field, including his coworker Jeffrey Hanson. Their combined expertise contributes to the success of their projects and the advancement of biopharmaceutical technologies.
Conclusion
Daniel Groff's contributions to biotechnology through his patents and work at Sutro Biopharma, Inc. highlight his role as a significant inventor in the field. His innovative approaches to protein production are paving the way for advancements in medical therapies.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.