The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2025
Filed:
Apr. 29, 2021
Applicant:
Sutro Biopharma, Inc., South San Francisco, CA (US);
Inventors:
Daniel Groff, Alameda, CA (US);
Jeffrey Hanson, Oakland, CA (US);
Assignee:
Sutro Biopharma, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); A61K 47/68 (2017.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
C12P 21/02 (2013.01); A61K 47/6851 (2017.08); C07K 16/32 (2013.01); C07K 2317/24 (2013.01);
Abstract
This disclosure provides a method of producing full-length antibodies inwith a yield of at least about 200 mg/L. Thecells typically have an oxidative cytoplasm, which is helpful for maintaining the three-dimensional structure and stability of proteins having disulfide bonds. In some cases, the molar ratio of the produced HC and LC amount from culturing theranges from about 1:1 to about 1:3 (e.g., from about 1:1 to about 1:2.5, from about 1:1 to about 1:2).