The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2025
Filed:
Jun. 29, 2022
Applicant:
Sutro Biopharma, Inc., South San Francisco, CA (US);
Inventor:
Daniel Groff, Alameda, CA (US);
Assignee:
Sutro Biopharma, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/20 (2006.01); C07K 14/47 (2006.01); C07K 16/00 (2006.01); C07K 16/32 (2006.01); C12N 9/00 (2006.01); C12N 9/02 (2006.01); C12N 9/12 (2006.01); C12N 9/90 (2006.01); C12N 15/52 (2006.01); C12N 15/70 (2006.01); C12P 21/02 (2006.01);
U.S. Cl.
CPC ...
C12N 1/205 (2021.05); C07K 16/32 (2013.01); C12N 9/0051 (2013.01); C12N 9/1252 (2013.01); C12N 9/90 (2013.01); C12N 9/93 (2013.01); C12N 15/52 (2013.01); C12N 15/70 (2013.01); C12Y 108/01009 (2013.01); C12Y 207/07007 (2013.01); C12Y 503/04001 (2013.01); C12Y 603/02002 (2013.01); C07K 2317/14 (2013.01);
Abstract
This disclosure provides anstrain, which lacks thioredoxin reductase activity encoded by trxB and thioredoxin 1 activity encoded by trxA, and glutathione reductase activity encoded by gor. Saidstrain expresses a mutated AhpC protein having glutathione reductase activity and a cytosolic prokaryotic disulfide isomerase. Thestrain has an oxidative cytosol and can be used to efficiently produce proteins having disulfide bonds.