Brian Fowler

Title: Innovations by Brian Fowler: A Leader in Microfluidics and Nucleic Acid Technology

Introduction

Brian Fowler, a prominent inventor based in San Mateo, California, holds an impressive portfolio of 22 patents. His work primarily focuses on advancements in microfluidics and nucleic acid technology, contributing significantly to the fields of sample processing and library preparation.

Latest Patents

Two of Fowler's latest patents exemplify his innovative approach to science and technology. The first, "Parallelized Sample Processing and Library Prep," describes methods, kits, and systems for sample enrichment, multi-step library preparation, sample normalization, and the detection of sample biomolecules. This invention highlights the use of microfluidic workflows and introduces sample barcoding methods designed to enhance sample throughput while minimizing background in negative samples. Additionally, it presents integrated microfluidic devices comprising sample processing unit cells connected to a variety of reaction sites for streamlined workflows.

The second patent, "Nucleic Acid Encoding Reactions," discusses methods to incorporate adaptors, nucleotide tags, and barcode sequences into target nucleotide sequences. This invention aims to generate nucleic acid fragments suitable for high-throughput DNA sequencing and encodes information about a reaction mixture into the final product. The patent also outlines methods for amplifying target nucleic acids in preparation for applications such as bidirectional nucleic acid sequencing and includes techniques for detecting and quantifying alleles through primer extension.

Career Highlights

Throughout his career, Brian Fowler has worked with leading companies in the biotechnology industry, notably Fluidigm Corporation and Standard Biotools Corporation. His contributions to these organizations have been pivotal in advancing research capabilities and enhancing experimental methodologies.

Collaborations

Fowler has collaborated with notable colleagues, including Andrew Paul May and Marc Alexander Unger. Together, they have propelled innovation and fostered developments in their respective fields through shared expertise and cooperative efforts.

Conclusion

Brian Fowler's innovative work and extensive patent portfolio underscore his significant contributions to the fields of microfluidics and nucleic acid technology. With ongoing advancements, Fowler continues to influence the landscape of biotechnology, making lasting impacts on research and application in the science community.