Location History:
- Moraga, CA (US) (1999 - 2002)
- Carmel, IN (US) (2004 - 2009)
Company Filing History:
6 out of 1,008 
2 out of 70 
1 out of 6 
Years Active: 1999-2009
Title: Armen B Shanafelt: Innovator in Pharmacological Peptides
Introduction
Armen B Shanafelt is a notable inventor based in Carmel, IN (US), recognized for his contributions to the field of pharmacological peptides. With a total of 12 patents, his work focuses on innovative therapies that address metabolic diseases and immune responses.
Latest Patents
One of his latest patents is for the development of pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use. This invention provides novel peptides that function in vivo to stimulate insulin release from pancreatic beta cells in a glucose-dependent manner. These insulin secretagogue peptides have been shown to stimulate insulin release in rat islet cells both in vitro and in vivo. The peptides offer a new therapy for patients with decreased endogenous insulin secretion, particularly type 2 diabetics. The invention includes a polypeptide selected from a specific group of VIP/PACAP-related polypeptides or their functional equivalents. Additionally, the invention outlines a method for treating metabolic diseases in mammals by administering a therapeutically effective amount of these insulin secretagogue peptides. Methods for making the peptides, both recombinant and synthetic, are also disclosed.
Another significant patent involves interleukin-9 antagonist muteins and their pharmacological methods of use. This invention relates to IL-9 muteins that inhibit the activity of wild-type IL-9, multimers, and Fc-fusion constructs of IL-9 proteins. It also provides an efficient method to purify IL-9 proteins produced by eukaryotic cells. The related formulations, dosages, and methods of administration offer therapeutic options for individuals with conditions where inhibiting IL-9 mediated immune responses would be beneficial, such as allergies, asthma, chronic obstructive pulmonary disease, inflammation, immunological disorders, leukemia, and lymphoma.
Career Highlights
Throughout his career, Armen has worked with prominent companies, including Bayer Corporation and Bayer Pharmaceuticals Corporation. His innovative work has significantly impacted the pharmaceutical industry, particularly in the development of therapies for metabolic and immune-related conditions.
Collaborations
Armen has collaborated with notable colleagues, including Jeffrey M Greve and Robert Gundel, contributing to advancements in pharmacological research and development.
Conclusion
Armen B Shanafelt's contributions to the field of pharmacological
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.