The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2006
Filed:
Apr. 17, 2004
Armen B. Shanafelt, Carmel, IN (US);
Jeffrey M. Greve, Berkeley, CA (US);
Gary Jesmok, Richmond, CA (US);
Kenneth Lembach, Danville, CA (US);
Gayle D. Wetzel, Martinez, CA (US);
Armen B. Shanafelt, Carmel, IN (US);
Jeffrey M. Greve, Berkeley, CA (US);
Gary Jesmok, Richmond, CA (US);
Kenneth Lembach, Danville, CA (US);
Gayle D. Wetzel, Martinez, CA (US);
Other;
Abstract
The invention is directed to a polypeptide comprising a human IL-2 mutein numbered in accordance with wild-type IL-2 wherein said human IL-2 is substituted at at least one of positions 20, 88 or 126, whereby said mutein preferentially activates T cells over NK cells. D20H and I, N88G, I, and R, in particular have a relative T cell-differential activity much greater than native IL-2, with predicted associated reduced in vivo toxicity. The invention also includes polynucleotides coding for the muteins of the invention, vectors containing the polynucleotides, transformed host cells, pharmaceutical compositions comprising the muteins, and therapeutic methods of treatment.